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MK-677 Ibutamoren

Buy Ibutamoren MK-677 For Sale Online From Direct Sarms America

MK-677, also known as Ibutamoren, is a growth hormone secretagogue that stimulates the release of both growth hormone (GH) and insulin-like growth factor 1 (IGF-1). Research suggests that this compound holds potential in treating various clinical conditions, such as growth hormone deficiencies, muscle-wasting diseases, and osteoporosis. Studies indicate that MK-677 for sale America may support muscle hypertrophy, enhance recovery times, and improve body composition. Additionally, it has shown promise in increasing bone mineral density and promoting joint health.

What is MK-677?

MK-677 America, also known as Ibutamoren, is a non-peptide growth hormone secretagogue. It effectively increases the secretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) by stimulating the pituitary gland, without affecting cortisol levels.

Cortisol, a stress hormone, can negatively impact the immune system, wound healing, and cognitive functions when elevated. Unlike other growth hormone supplements that may raise cortisol levels and suppress natural GH production, MK 677 delivers similar benefits without these adverse effects.

Ibutamoren works by emulating the effects of ghrelin, a natural hormone that controls the release of growth hormone (GH). Unlike direct hormone injections, MK-677 stimulates the body’s own production of these hormones, thereby maintaining more stable and physiological levels.

This mechanism makes MK-677 a subject of interest for its potential therapeutic applications, particularly in conditions characterised by a deficiency in growth hormone or reduced bone density. Its ability to promote muscle growth, enhance recovery, and improve overall body composition further solidifies its stature in the realm of sports science.

How Does MK-677 Work?

MK-677, also referenced as Ibutamoren, functions by mimicking the action of the hormone ghrelin, which plays a significant role in regulating appetite and growth hormone release. Upon administration, MK-677 binds to ghrelin receptors, initiating a cascade that leads to the secretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1).

This stimulation of endogenous GH production offers a more balanced hormonal profile compared to exogenous hormone administration. By enhancing GH and IGF-1 levels, MK-677 supports muscle hypertrophy, improved bone density, and accelerated recovery times. 

For America researchers looking to buy MK-677, understanding its mechanisms can provide insights into its potential applications in both clinical and sports science settings. This compound’s ability to elevate growth hormone levels without direct hormone injections makes it a valuable tool for exploring therapeutic strategies for conditions like growth hormone deficiencies and muscle-wasting diseases.

MK-677 Specifications

MK677 StructureMolecular Formula: C27H36N4O5S

Molecular Weight: 528.7 g/mol

Sequence: 2-Amino-N- (3-(benzyloxy) -1- (1-(methylsulfonyl) spiro[indoline-3,4′-piperidin]-1′-yl) -1-oxopropan-2-yl) -2-methylpropanamide

PubChem CID: 9939050

Source: PubChem

View the High-Performance Liquid Chromatography (HPLC) Certificate here.

What are the suggested research benefits of MK-677?

  • Enhances Growth Hormone Levels: Ibutamoren significantly increases the secretion of growth hormone (GH levels), contributing to muscle mass hypertrophy and accelerated recovery times, making it a valuable research chemical.
  • Improves Body Composition: Research on MK 677 indicates its potential to promote lean body mass growth while aiding in fat loss, thus improving overall body composition among clinical trial participants, including obese males and healthy young adults.
  • Metabolic Health Research: Current investigations are exploring Ibutamoren’s potential impacts on metabolic health. This includes its capacity to improve nitrogen balance and elevate energy expenditure. Such attributes could prove beneficial in managing obesity and associated metabolic conditions, highlighting MK 677’s therapeutic promise.
  • Supports Bone Density: Studies have shown that Ibutamoren can enhance bone mineral density, suggesting its potential as an effective treatment for conditions like osteoporosis in older adults.
  • Accelerates Muscle Recovery: By boosting growth hormone release and insulin-like growth factor 1 (IGF-1), Ibutamoren facilitates quicker muscle recovery, beneficial for both clinical trials and athletic performance contexts.
  • Enhances Sleep Quality: Ibutamoren has shown to significantly improve sleep quality, including REM sleep and overall sleep duration, which is vital for optimal health and recovery.
  • Non-invasive Hormone Modulation: Unlike direct hormone injections, MK-677 induces the body’s own production of growth hormone, thereby supporting a more natural and stable hormonal profile.
  • Potential Therapeutic Applications: Ongoing clinical studies are exploring the use of Ibutamoren as a treatment for growth hormone deficiencies, muscle-wasting diseases, cognitive function decline, and conditions like Alzheimer’s disease.
  • Joint Health Support: Research indicates that MK 677 may promote joint health, enhancing both clinical outcomes and athletic performance.
  • Cognition Enhancement: Emerging studies suggest that MK-677 may support brain health and cognitive processes, potentially aiding memory and learning abilities.
  • Enhances Libido: Investigations have suggested that MK 677 may positively affect libido, likely due to its regulation of GH and IGF-1 levels, contributing to overall hormonal balance and sexual health.
  • Anti-Aging Benefits: Aging individuals may experience improved hormone profiles by taking Ibutamoren, as it helps to elevate their diminishing growth hormone (GH) levels. In a randomized trial involving 65 elderly participants, daily Ibutamoren successfully increased GH and IGF-1 levels to those observed in healthy young adults, without causing serious adverse effects. This suggests that MK-677 for sale America, could be a valuable compound for addressing age-related hormone decline and enhancing overall hormonal balance in older adults.

What MK-677 products are available?

Buy MK-677 Liquid Droppers

MK677 Liquid Dropper

Buy Ibutamoren Liquid, 50ml bottle containing 1250mg MK-677 for sale for clinical research from America Direct Sarms. MK-677 Liquid is an effective and convenient form of Ibutamoren that researchers prefer for its ease of administration and precise dosing.

This liquid format ensures rapid absorption and assimilation, providing consistent results in growth hormone and insulin-like growth factor 1 (IGF-1) stimulation.

When considering the best place to buy MK-677, our platform offers high-quality Ibutamoren Liquid, ensuring reliability and purity for your research needs. With Ibutamoren MK-677 for sale, this liquid preparation facilitates various experimental protocols, making it an essential addition to any researcher’s toolkit.

Capsule Blend RAD-140 and MK-677 For Sale

mk677 RAD140Buy MK-677 & RAD-140 20 mg Capsules Blend for research from Direct Sarms America. The blended stack combines the benefits of two potent compounds to support muscle growth and fat loss in research.

MK-677, known for its ability to stimulate the release of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), works synergistically with RAD140, a selective androgen receptor modulator (SARM) recognised for its anabolic properties.

This blend aims to enhance muscle hypertrophy, accelerate recovery times, and improve overall body composition without the need for exogenous hormone administration. America Researchers looking to buy MK 677 or find MK-677 for sale can explore this blend as a versatile option for various experimental protocols, providing a robust approach to studying muscle growth and metabolic enhancement.

About MK 677 and Stacks

Post Cycle Therapy (PCT)

Post Cycle Therapy (PCT) is an essential process undertaken after the conclusion of a cycle involving anabolic steroids or certain performance-enhancing drugs (PEDs). The primary objective of PCT is to help restore the body’s natural hormonal balance, which may be disrupted during the use of these substances.

By encouraging the resumption of normal testosterone production and mitigating the effects of suppressed hormone levels, PCT aims to preserve muscle gains while reducing the risk of adverse side effects.

Typical components of PCT protocols include Selective Estrogen Receptor Modulators (SERMs) like Clomid or Nolvadex, Aromatase Inhibitors (AIs), and sometimes human chorionic gonadotropin (hCG). Effective PCT is crucial for maintaining health and ensuring the long-term success and safety of an enhancement cycle.

post cycle therapy support front


Post Cycle Therapy Supplements are available to buy from America Direct Sarms. Visit our main Support Supplements page to explore the full range of cycle support.

Buy MK677 and GW501516

Combining MK677 (Ibutamoren) with GW501516 (Cardarine) offers synergistic benefits for research. MK 677 increases growth hormone and IGF-1 levels, aiding muscle mass, recovery, and body composition. GW-501516 enhances endurance and fat metabolism by activating the PPAR-delta pathway, leading to greater fat loss and performance.

Together, Ibutamoren and Cardarine provide a comprehensive approach to body recomposition and athletic efficiency. Researchers may observe accelerated muscle growth from MK 677 and increased stamina and fat reduction from GW501516. This combination offers insights into muscle preservation, fat reduction, and metabolic health.

Explore the primary GW-501516 category page to learn more about this peroxisome proliferator-activated receptor (PPAR) agonist.

It’s crucial that research involving these compounds is conducted in a controlled environment, adhering to ethical standards and regulatory guidelines.

LGD-4033 and MK-677 For Sale

Stacking LGD-4033 (Ligandrol) with MK677 (Ibutamoren) offers a potent combo for research into muscle mass enhancement and body composition. LGD-4033, a selective androgen receptor modulator (SARM), significantly increases muscle strength and lean body mass without the severe side effects of traditional anabolic steroids. MK 677 boosts these effects by increasing growth hormone and IGF-1 levels, promoting muscle growth, enhanced recovery, and improved body composition.

Together, LGD-4033 and MK 677 can potentially provide rapid gains in muscle size and strength, faster recovery due to elevated growth hormone levels, and improved fat oxidation and metabolism. This stack is of particular interest for research into muscle wasting, osteoporosis, and metabolic function. Visit our main LGD-4033 page to further details on this SARM.

However, careful attention to dosage, cycle length, and post-cycle therapy (PCT) is essential to mitigate potential side effects and ensure research safety and effectiveness. Compliance with ethical standards and regulatory guidelines is crucial when conducting studies with these compounds.

Frequently Asked Questions (FAQ’s) about MK-677 Peptides

What are the shipping policies for Direct Sarms?

Direct Sarms America offers worldwide shipping for their research compounds, including their MK-677 for sale. They provide tracking information for all orders to ensure transparency and security. Shipping costs and delivery times vary based on destination and shipping method. America Customers can review the shipping policy on Direct Sarms’ website for details on delivery times, fees, and international restrictions. 

Is MK-677 legal to buy?

MK-677, also known as Ibutamoren, is legal to purchase for research purposes in many regions, including the USA. However, it is not approved for human consumption or use as a dietary supplement.

Regulatory bodies such as the FDA (Food and Drug Administration) in the United States, the TGA (Therapeutic Goods Administration) in Australia, and the MHRA (Medicines and Healthcare products Regulatory Agency) in the United Kingdom have not authorised MK-677 for these purposes.

This product is intended for laboratory research purposes only and not for human consumption. The use of the product should be strictly in accordance with practices of a reliable person, with adherence to the Toxic Substances Control Act (TSCA) and any other applicable regulations.

America Researchers must comply with regional regulations and guidelines when searching MK-677 for sale online to ensure adherence to legal and safety requirements.

Are there any side effects associated with MK-677?

Potential side effects of MK-677 may include increased appetite, mild swelling or edema, joint pain, and insulin resistance. It is essential to conduct thorough research and consult relevant scientific literature to understand the safety profile of MK-677 in your specific research context.

Does MK-677 affect appetite?

Yes, MK-677 has been shown to affect appetite. It mimics the hormone ghrelin, which regulates appetite, leading to an increase in hunger. This side effect can be beneficial for muscle growth and recovery due to increased caloric intake, but it can also be challenging when calorie control is necessary.

America Researchers should consider the appetite-stimulating effects of MK-677 in their studies and account for its impact on dietary intake and body composition.

Can MK-677 be used in combination with other compounds?

MK-677 may be used in combination with other compounds such as selective androgen receptor modulators (SARMs) in research studies to investigate synergistic effects and optimise research outcomes. Researchers should ensure that the combination of compounds is safe and efficacious based on prior scientific evidence and conducted under rigorous research protocols.

What makes MK-677 different from direct growth hormone injections?

Unlike direct growth hormone injections, MK-677 stimulates the body’s own production of GH and IGF-1, leading to more stable and physiological levels. This endogenous stimulation may offer a more balanced hormonal profile and reduce the risks associated with exogenous hormone administration.

More detailed information about this subject can be found in our blog post MK 677 vs HGH.

Further Reading

For more information, explore our latest blog posts dedicated to MK-677 peptides.

Buy Ibutamoren MK-677 For Sale Online Today!

MK-677, also known as Ibutamoren, stands out as an exceptional growth hormone secretagogue that has captured the interest of researchers worldwide. Renowned for its ability to enhance growth hormone levels, improve body composition, support bone and joint health, and potentially boost cognitive function, MK-677 is a versatile and valuable compound for various research applications.

Direct Sarms America offers a comprehensive range of MK-677 for sale, including capsules, liquids, powders, stacks and PCT bundles, ensuring researchers have the precise format they need for their experimental protocols. Our high-quality MK-677 products guarantee reliability and purity, making them an excellent choice for studies on muscle mass hypertrophy, sleep quality enhancement, libido enhancement, and more.

Scientific References

[1] G.J.Hickey, T.M.Jacks, K.D.Schleim, et al (1997) Repeat administration of the GH secretagogue MK-0677 increases and maintains elevated IGF-I levels in beagles – Journal of Endocrinology, 1997 Feb; Volume 152(Issue 2): pages 183-92.

[2] M.G.Murphy, L.M.Plunkett, B.J.Gertz, et al (1998) MK-677, an Orally Active Growth Hormone Secretagogue, Reverses Diet-Induced Catabolism – The Journal of Clinical Endocrinology & Metabolism, Volume 83, Issue 2, Pages 320-325, 1 February 1998.

[3] R.Nass, S.S.Pezzoli, M.C.Oliveri, et al (2008) Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial – Annals of Internal Medicine, 2008 Nov 4, Volume 149 (number 9), Pages 601-11.

[4] D.M.Ney (1999) Effects of insulin-like growth factor-I and growth hormone in models of parenteral nutrition – JPEN. Journal of Parenteral Enteral Nutrition, 1999 Nov-Dec, Volume 23 (6 Supplement), Pages S184-9.

[5] J.T.Sigalos and A.W.Pastuszak (2018) The Safety and Efficacy of Growth Hormone Secretagogues – Sexual Medicine Reviews,Volume 6, Issue 1, January 2018, Pages 45-53.

[6] T.Thum, F.Fleissner, I.Klink, et al (2007) Growth hormone treatment improves markers of systemic nitric oxide bioavailability via insulin-like growth factor-I – Journal of Clinical Endocrinology & Metabolism, Volume 92, Issue 11, 1 November 2007, Pages 4172–4179.

[7] G.Copinschi, R.Leproult, A.V.Onderbergen, et al (1997) Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man – Neuroendocrinology, 1997 Oct, Volume 66 (Issue 4), Pages 278-86.


DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our America Direct Sarms website is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.