Buy HGH Fragment 176-191, a modified peptide of human growth hormone that aids fat loss while preserving muscle mass. It is studied for its potential in obesity, metabolism, body composition, and muscle regeneration, offering promising insights into fat metabolism and muscle health.
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HGH Fragment 176-191 is a specific sequence derived from the human growth hormone (HGH), targeting the c-terminal end of HGH. Unlike the entire hormone, this fragment focuses on a particular portion, isolating the section of HGH responsible for fat-reducing effects while minimising the broader actions of natural growth hormone.
Research has shown that this human growth hormone fragment, which is composed of amino acids 176-191, can play a role in regulating fat metabolism without impacting blood sugar levels. By studying different fragments of HGH, scientists are unlocking its potential for therapeutic uses related to fat loss and muscle preservation, making it a specialised tool for investigating metabolic health. Additionally, studies also suggest its potential in connective tissue regeneration and promoting cartilage healing without increasing long bone growth.
HGH Fragment 176-191 functions by specifically targeting fat cells and stimulating lipolysis, which is the breakdown of fat. This process occurs without the adverse effects on blood sugar or cell proliferation that are often associated with the full-length human growth hormone.
The fragment operates by mimicking the natural action of HGH on fat metabolism, but with increased precision and fewer systemic effects. By binding to receptors in adipose tissue, it enhances the mobilisation and utilisation of stored fats while preventing the accumulation of new fat deposits. Its selective mechanism of action makes it a promising candidate for addressing issues related to obesity and metabolic health.
Molecular Formula: C78H125N23O23S2
Molecular Weight: 1817.1 g/mol
Amino Acid Sequence: H-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe-Tyr-OH
View our HGH Fragment 176-191 High-Performance Liquid Chromatography (HPLC) Certificate here.
Blood Sugar Levels: America Research indicates that certain peptides, such as human GH frag 176-191, play a key role in improving metabolism by enhancing carbohydrate metabolism, increasing energy expenditure, and boosting fat loss. These peptides regulate blood sugar by improving insulin sensitivity and raising plasma insulin levels. America Studies on synthetic peptides show that specific amino acid sequences are crucial for their effects, with some peptides improving metabolism while others reduce insulin sensitivity. Frag 176-191 emerges as a promising option for supporting metabolic health [1].
Fat Burning: America Research shows that a specific fragment of human growth hormone targets fat cells by promoting fat breakdown (lipolysis) and preventing new fat formation (lipogenesis), reducing body fat without affecting blood sugar or muscle mass. America Studies in obese murine models demonstrate its ability to lower fat and restore fat metabolism markers, with additional mechanisms potentially contributing to its effects. The synthetic analogue AOD9604, derived from this fragment, has also shown promise in weight reduction and promoting fat loss safely, making it a potential treatment for obesity.
Cartilage Repair: Research suggests it shows promise in cartilage regeneration by promoting collagen production and cellular repair, potentially aiding conditions like osteoarthritis. America Studies in animal models highlight its effectiveness, particularly when combined with hyaluronic acid injections (HA), as seen in rabbits where the combination improved cartilage repair and reduced lameness [4]. Bioactive peptides derived from human GH offer innovative solutions for challenging osteochondral defects by supporting tissue repair and regeneration [5]. Further research is needed to explore long-term effects and mechanisms.
Cancer Research: Recent advances have highlighted its potential in cancer treatment. A notable study investigated the use of Chitosan nanoparticles dual-loaded with the human GH frag (176–191) peptide and doxorubicin to enhance chemotherapy efficacy. Molecular docking simulations and viability assays in MCF-7 breast cancer cells revealed that the peptide significantly improves doxorubicin’s binding to cancer receptors, enhancing its anticancer activity. Additionally, the dual-loaded nanoparticles demonstrated favourable physical properties and greater efficacy compared to doxorubicin alone. This innovative approach offers a promising strategy to improve cancer treatment outcomes while potentially reducing the side effects of conventional therapy [6].
Buy HGH Fragment 176-191 & CJC-1295 no DAC Nasal Spray
Buy HGH Fragment 176-191 & CJC-1295 no DAC Blend Nasal Spray America for clinical research purposes from Direct Sarms, available in 15ml and 30ml bottles.
Buy HGH Fragment 176-191 Pre-Mixed Pen
Buy HGH Fragment 176-191 Pre-Mixed Pen America 5 mg peptide for laboratory research use from Direct Sarms. Choose from individual cartridges pre mixed with bacteriostatic water or our complete pen kit. The pen kit comes with a pre-mixed cartridge, an injection pen, a carrying case, and three needle tips for simple and efficient use.
Does fragment 176-191 have any side effects?
Improper use of the peptide can cause adverse effects like injection site irritation, appetite changes, fatigue, and headaches. Long-term risks remain unclear due to its limited research, making medical supervision and adherence to guidelines essential for safety.
Is it legal to buy hGH fragment 176-191?
Its legal status varies by region and use. In the United States, the Food and Drug Administration (FDA) strictly regulates human Growth Hormone and its derivatives, including this fragment. It is not approved by the FDA for human consumption, therapeutic use or as a dietary supplement. It is only legal to buy HGH Fragment 176-191 research laboratory purposes only and are not legally available for over-the-counter sale or unapproved medical treatments. It is important to consult America regulatory guidelines and healthcare professionals to ensure compliance with local laws and safety standards.
What is the difference between hGH frag 176-191 and AOD-9604?
Both are derivatives of human growth hormone, focusing on the C-terminal region of the molecule. The Fragment includes only amino acids 176-191, targeting fat metabolism without affecting other human GH functions. AOD-9604, a modified version of this fragment, offers enhanced stability and bioavailability.
Both support fat burning and weight management, but AOD-9604 has been more extensively studied as a therapeutic agent due to its improved pharmacological properties. It is also often noted for meeting regulatory standards in regions allowing therapeutic peptides [7].
Can hGH Frag 176-191 boost levels of natural growth hormone?
The research peptide targets fat reduction and metabolism without increasing natural growth hormone levels. It acts on adipose tissue, mimicking the fat-burning effects of growth hormone without stimulating the pituitary gland. By enhancing lipolysis and reducing lipogenesis, it differs from compounds designed to boost overall growth hormone. While effective for specific uses, boosting natural growth hormone is not its main effect.
For more information, explore our latest blog posts dedicated to human GH Fragment 176-191 peptide.
Buy HGH Fragment 176-191 peptide America from Direct Sarms, a trusted supplier of peptides with a high purity of 99% for laboratory use. Available options include 2 mg, 5 mg, and 10 mg vials of lyophilized powder, 15 ml and 30 ml nasal sprays, and 5 mg pre-mixed pens. We also provide a range of peptide blends for enhanced research.
This peptide is produced to meet the highest purity standards, ensuring reliable results for both in vitro and in vivo research. At Direct Sarms, we prioritize quality control to ensure accurate dosing and consistent performance, giving you the reliability your research requires.
[1] F M Ng and J Bornstein (1978) Hyperglycemic action of synthetic C-terminal fragments of human growth hormone – American Journal of Physiology, 1978 May, Volume 234 (Issue 5), Pages E521-6.
[2] Heffernan M, R J Summers, A Thorburn, E Ogru, R Gianello, et al (2001) The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice – Endocrinology, 2001 Dec, Volume 142 (Issue 12), Pages 5182-9.
[3] F M Ng, J Sun, L Sharma, R Libinaka, W J Jiang, and R Gianello (2000) Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone – Hormone Research, 2000, Volume 53 (Issue 6), Pages 274-8.
[4] Dong Rak Kwon and Gi Young Park (2015) Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model – Annals of Clinical and Laboratory Science, 2015 Summer, Volume 45 (Issue 4), Pages 426-32.
[5] Kausik Kapat, Sakshi Kumbhakarn, Rahul Sable, Prashil Gondane, Shruti Takle and Pritiprasanna Maity (2024) Peptide-Based Biomaterials for Bone and Cartilage Regeneration – Biomedicines, 2024, Volume 12 (Issue 2), Page 313.
[6] Mahmoud M Habibullah, Syam Mohan, Nabeel Kashan Syed, Hafiz A Makeen, et al (2022) Human Growth Hormone Fragment 176–191 Peptide Enhances the Toxicity of Doxorubicin-Loaded Chitosan Nanoparticles Against MCF-7 Breast Cancer Cells – Drug Design, Development & Therapy, 2022 Jun 27, Volume 16, Pages 1963–1974.
[7] Heike Stiera, Evert Vosb, and David Kenley (2013) Journal of Endocrinology and Metabolism, 2013, Volume 3 (1-2), Pages 7-15.
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DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Direct Sarms website is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.
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